Can I drink while on medication?

To find out the facts we spoke to our Chief Medical Advisor, Professor Paul Wallace.

We asked Professor Paul Wallace why doctors sometimes tell us not to drink when we take prescription drugs, and what happens if we do. Professor Wallace says it depends what medication you have been prescribed. For most, it is fine to drink within the government’s lower risk guidelines. However, for some, alcohol should be completely avoided.

Professor Wallace says that:

  • People taking sedative drugs (like diazepam/Valium) or antidepressants (like fluoxetine/Prozac) should avoid alcohol altogether
  • People taking long-term medications should be careful about drinking, as alcohol can make some drugs less effective, meaning long term conditions get worse. Examples include, people taking drugs for epilepsy or diabetes, or drugs like warfarin to thin the blood.
  • There are some antibiotics which simply do not mix with alcohol - drinking with these will make you sick. But for most commonly prescribed antibiotics, drinking is unlikely to cause problems so long as it is within the daily unit guidelines
  • There’s no evidence about the effects of alcohol on your immune system – the benefits of a hot toddy are probably all in our head.

Read on to find out more about all of the above.

How alcohol can interfere with medication

Professor Wallace says there are two main reasons why doctors advise patients not to drink with some drugs.

“Firstly, because alcohol is a depressant, it affects the way your brain works, numbing your senses so they don’t operate properly,” he says.

“Some types of medication also affect the way your brain works, and if you’re drinking alcohol there will be a conflict. Alcohol will increase the sedative effects of both, causing sleepiness and dizziness. It could also change the way the brain responds to the medication, making it less effective.”

If you’re taking a sedative drug such as diazepam/Valium, or any other drug that can make you drowsy, and you drink alcohol, your reaction times could decrease and you’ll get tired faster. If you’re driving or operating machinery, this can be extremely dangerous.

“Secondly, alcohol can affect the way drugs are absorbed by the body and broken down in the liver,” says Professor Wallace.

"If you drink alcohol regularly and especially if you drink excessive amounts, your liver produces more enzymes so that it can get rid of the alcohol more quickly. Those same enzymes might break down the medication you are taking so it no longer has the same effect. An example of this is medications for epilepsy".

Alcohol and antibiotics

When it comes to antibiotics, Professor Wallace says that the message is slightly different than it is with sedative drugs. The NHS advises that people who choose to drink alcohol when taking most common antibiotics do so within the lower risk guidelines. (1)

There are antibiotics, like Metronidazole and Tinidazole, which you should not drink alcohol with.  Mixing them with alcohol can lead to nausea, vomiting, flushing of the skin, accelerated heart rate or shortness of breath. This is because they can interfere with the breakdown of alcohol, leading to the production of nasty side effects (2).

There are a wide variety of antibiotics available, penicillin and amoxicillin are the most widely used. All of these can have different interactions with alcohol, and, as with any medication you should always consult with your doctor or pharmacist about the guidelines regarding consumption.

Statins and alcohol

Statins are drugs which are taken to lower the levels of cholesterol in your blood.  High levels of ‘bad cholesterol’ can increase the risk of developing cardiovascular disease due to fatty deposits building up in your arteries.

According to the NHS there are no known interactions between statins and alcohol (3). However, consumption of statins can occasionally result in an increase in liver enzymes, which if left unchecked can lead to liver damage. It is therefore important for those taking statins to stay within the government’s lower risk guidelines and to have their liver function tested periodically. As with any medication, you should always consult the guidelines of consumption with your doctor.

What is an alcohol unit and how many is too many?

Can alcohol make you better?

So, can alcohol itself ever be a good medicine? Historically it once had a very important medical application, says Professor Wallace.

 “Before the advent of modern anaesthetics, when surgeons were performing operations, they would use alcohol as an anaesthetic, getting their patients drunk before they operated,” he explains. Professor Wallace says the reason for this is because alcohol numbs the brain.

He explains that many people also feel better after having a hot toddy when they have a cold because alcohol also numbs your senses; a hot toddy can make you feel better but there’s no evidence to suggest that it actually improves your health.

“Nobody should kid themselves that it is going to help you actually get better,” says Professor Wallace. “You may experience an immediate gain because if you are feeling rotten alcohol might make you feel less bad for a short time. But the term ‘medicinal brandy’ is an oxymoron.”

Alcohol and the immune system

There’s no firm evidence about the effects of alcohol on the immune system, but Professor Wallace thinks it’s probably not a good idea to drink alcohol when you are feeling ill because it is likely to make you feel worse. “Our state of mind can affect the way we respond to illnesses and alcohol is, after all, a depressant,” says Professor Wallace.

Can alcohol ever be good for the heart?

Finding out if you can drink on your medication

If you’re taking prescription drugs and are unsure whether it is safe to drink alcohol, the best advice is to check with your doctor and the pharmacist. Also check the leaflet that comes with the medication.

“If it doesn’t say 'Don’t drink alcohol' it’s probably okay to drink within the lower risk guidelines," says Professor Wallace. "But if you are in any doubt, don’t drink alcohol at all because you could put your health at risk.”

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Page updated: March 2015